ACTH insensitivity is a cardinal feature of ALD, but the mechanism is unknown. We studied a 10 year old hyperpigmented boy with glucocorticoid insufficiency of 8 years duration and a history of ...

X-linked adrenoleukodystrophy (X-ALD) is a debilitating disease caused by mutations in the ABCD1 gene. Approximately 30% of affected boys develop the progressive ...

Regular MRI scanning of patients with ALD, both adults and children, is recommended so that care, counselling, and treatment for symptoms like adrenal insufficiency can start as soon as possible ...