Figure 6: The mechanism by which WNTs prevent the GSK3-catalysed phosphorylation of axin, APC and β-catenin ... The phosphorylation of the endogenous protein in cells should decrease in response ...

recognizes the ~312 kDa APC protein; stains the cell body as opposed to the myelinated processes, so is well suited for IHC and IF studies of oligodendrocytes ...

By using microscopy, flow cytometry, and proteomics, the researchers discovered that the enzyme APC/C, which normally targets proteins for degradation to regulate the cell cycle, helps maintain ...