For example, antifungal agents are often ... namely reduction in the concentration of the drug target—thus eliminating it as a site of action; changes in molecule biosynthesis; and pumps that ...

The accelerating pace of antimicrobial drug discovery has resulted ... depending on their site of action: the polyenes interact with fungal membrane–building blocks; azoles inhibit the synthesis ...

Although therapeutic first-line approaches have been established in severely immunosuppressed patients with a high risk of invasive fungal infections ... on mechanism of action and principles ...

The University of Exeter has launched a new round of funding to tackle the growing global challenge of fungal antimicrobial resistance (fAMR). The FAILSAFE project (Fungal AMR Innovations for ...

Without immediate action, humanity will potentially face ... either already resistant or rapidly acquiring resistance to ...

An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic ... used the known mode of action of fluorocytosine on A. fumigatus as the ...

The MRP rates on the drug indicated were significantly higher than the ceiling price fixed for the product under the Drugs (Prices Control) Order, 2013 by National Pharmaceutical Pricing Authority (c) ...