Ras proteins couple a wide variety of extracellular signals to specific intracellular signalling pathways. The extracellular signals activate Ras-specific guanine-nucleotide-exchange factors (GEFs ...

SMAD4 encodes the SMAD4 transcription factor that is activated by TGFβ signaling. The three RAS genes encode particularly identical (82–90%) 188–189 amino acid proteins (Figure 2).

Decades of research have shown that mutant RAS proteins promote the development and growth of tumors by activating specific ...

For children with severe hypertrophic cardiomyopathy caused by gain-of-function RAS/mitogen-activated protein kinase ( ...

Additionally, the Phase 1 clinical trial evaluating QTX3034, an oral G12D-preferring multi-KRAS inhibitor, as a monotherapy and in combination with cetuximab, continues to enroll patients, and data is ...

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy ...

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS/MAPK ...