Acyclovir gets converted to acyclovir triphosphate, which then inhibits replication of herpes viral DNA by competitively inhibiting viral DNA polymerase, incorporating into and terminating the ...

Acyclovir (as sodium ... All: max 20mg/kg every 8 hours. Obese: dose based on ideal body weight. Renal impairment: CrCl 25–50mL/min: give dose every 12 hours; CrCl 10–25mL/min: give dose ...

The use of post-exposure acyclovir prophylaxis in immunocompetent children exposed to a household contact with varicella has been shown to decrease the transmission rate of varicella significantly.

BACKGROUND: Diagnosis and management of Acute Retinal Necrosis (ARN) in children that does not respond to systemic acyclovir treatment can be challenging. We report two cases of ARN secondary to ...