Our group discovered the CAPA pathway while identifying endocytic regulators. Adaptor proteins (APs) are heterotetrameric complexes that function on distinct organelles during clathrin-dependent and ...

Clathrin (blue) forms multiple complexes based on its association with different adaptor proteins (APs). Clathrin that is associated with AP1 and AP3 forms vesicles for transport from the trans ...

The research is published in the journal Nature Communications. During clathrin-mediated endocytosis, adaptor proteins bind to the cell membrane and to the protein clathrin, assisting in engulfing ...