It was generally assumed that these receptors existed as monomers and coupled to G proteins in a 1:1 stoichiometric ratio. However, these classical models of receptor/G protein coupling may be ...

Beginning with the β2-adrenergic receptor in 1982, Lefkowitz isolated eight of the nine subtypes of adrenergic receptors and determined their complete amino acid sequences. The βadrenergic receptors ...

"β-Arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor," J Biol Chem ... The team blocked the G protein-dependent portion of the signaling pathway by using three ...