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Akt2 抑制:缓解颞下颌关节骨关节炎的新希望
综合研究结果和讨论,此项研究表明 Akt2 通路在 ADD 诱导的 TMJOA 早期主要在软骨下骨巨噬细胞中激活,对调节软骨下骨重塑起着关键作用。抑制 Akt2 能够减轻关节软骨和软骨下骨的退行性改变,可作为 ADD 后延缓 TMJOA 进展的预防性治疗手段。不过,该研究也存在一定局限性,如 shAkt2 ...
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