The Institute of Cancer Research played a crucial role in the development of alkylating agents and cisplatins – two important classes of chemotherapy agents which are still in wide spread use today.

Chemotherapy is one of the most-used cancer ... “By damaging the DNA, alkylating agents stop cancer cells from replicating. However, because they affect all rapidly dividing cells, they can ...

In contrast, alkylating agents do not become toxic ... dose-intensity calculations to allow comparison among various chemotherapy regimens. The unit dose intensity (UDI) required to produce ...

Chemotherapy - Chemotherapy is an increasingly important aspect of cancer treatment. Alkylating agents, which work by impairing cell division, and antimetabolites, which interfere with the enzymes ...

By substituting doxorubicin for epirubicin and ifosfamide for cyclophosphamide, we aimed to evaluate the possible lack of cross-resistance between the two anthracyclines and the two alkylating agents.