Enzyme activity is tightly regulated in living organisms to maintain homeostasis and respond to changing conditions. Enzymes can be regulated by various means, such as allosteric regulation (binding ...

"This is the second allosteric TYK2 inhibitor we have advanced into the clinic this year, after SUDO-286 which is progressing in two Phase 1 trials as a topical treatment for psoriasis." ...

Our work encompasses a broad range of molecular mechanisms of action, spanning covalent inhibitors, allosteric inhibitors, enzyme activators, protein (or protein complex) stabilizers, and protein ...

ETX-636 is a novel orally bioavailable allosteric pan-mutant-selective PI3Kα inhibitor and degrader. This dual mechanism of action results in deep and durable pathway inhibition and induces ...

In a study published in Nature Methods, a research group developed a highly sensitive proteomics method called ...

TERN-701 showed promising early results, with significant molecular responses and a strong safety profile in heavily ...

The presentation will feature preclinical characterization of LAE118, a novel allosteric pan-mutant selective PI3Kα inhibitor. "We appreciate this recognition of our expertise and strength in pre ...

This prestigious grant of US$4.75 million will support the clinical development of Eisbach's first-in-class allosteric small molecule inhibitor EIS-12656 targeting ALC1, a chromatin remodeling enzyme ...