Allosteric activators or inhibitors induce small conformational changes that can either turn on or turn off an enzyme. X-ray crystallography and protein 'docking' experiments are creating new ...
The principle of allosteric regulation, in which ligand-binding at one protein site triggers functional ... which they then linked to the bacterial metabolic enzyme dihydrofolate reductase ...
A new study, "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein" published in Biochemistry, provides key insights into how bacterial cAMP receptor proteins (CRPs ...
The research, titled "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein through Structural Homology," was led by Dr. Rodrigo Maillard at Georgetown University.
A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...
A three-dimensional image showing the human protein PSD95-PDZ3 from different ... colour gradient indicating increasing potential for allosteric effects. Based on PDB accession 1BE9.
Enzymes are primarily proteins, although some RNA molecules called ribozymes also exhibit enzymatic ... Enzymes can be regulated by various means, such as allosteric regulation (binding of effector ...
Our work encompasses a broad range of molecular mechanisms of action, spanning covalent inhibitors, allosteric inhibitors, enzyme activators, protein (or protein complex) stabilizers, and protein ...
Washington, D.C. – A new study, “Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein” published in Biochemistry, provides key insights into how bacterial cAMP ...
Kinases are enzymes which modify their targets ... Constrained TACC3 peptidomimetics for a non-canonical protein–protein interface elucidate allosteric communication in Aurora-A kinase, Chemical ...
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Bacterial species study challenges assumption that structural similarity predicts protein ...More information: Stephen P. Dokas et al, Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein through Structural Homology, Biochemistry (2025). DOI: 10.1021/acs ...
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