Ideally one would like to be able to mutate each residue to a variety of different amino acids, and assess the effects of these mutations both alone and in combination with other mutated residues.

Binding is the first step for infection, and several mutations in previous variants of concern have been shown to be important for increasing the spike's binding to human ACE2. “We simulated the ...

Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects ...

swapping around the amino acids can essentially break a protein. "Missense" mutations — changes in a DNA sequence that swap one amino acid for another — in nearly 5,000 human proteins are ...

Narrator: Mutation has become a sort of genetic boogeyman ... And a combination of three nucleic acids corresponds to a single amino acid. Narrator: String those amino acids together ...

A comprehensive analysis of over 500,000 human protein variants reveals that 60% of disease-causing missense mutations reduce protein stability A comprehensive analysis of over 500,000 human ...

However, most DNA mutations do not alter a protein. One reason is because several different triplets can code for the same amino acid. Other mutations may only alter the protein slightly so its ...

By modifying a specific amino acid cysteine to serine residue at position 328 in vimentin, they discovered that this mutation disrupted the protein's interaction with the cell's structural network.

This important study uses advanced computational methods to elucidate how environmental dielectric properties influence the interaction strengths of tyrosine and phenylalanine in biomolecular ...

As the bases are read in threes' (triplet code) this may result in a different amino acid being synthesised, and therefore possibly a different protein. eg CAC / ACC/ CGA These mutations may ...