Amyloid β protein (Aβ) deposition in the brain is a hallmark ... PBS and lysed in 1% Triton X-100 in PBS containing protease inhibitors (5 μg per ml pepstatin, 100 μg per ml phenylmethylsulpho ...

Genetic and biological studies provide strong evidence that the deposition of amyloid-ß peptide (Aß ... development have enabled some secretase inhibitors and modulators to advance into late ...

A consensus has emerged among many investigators that cerebral accumulation of the amyloid β-protein (Aβ ... step toward attempting to image brain Aβ deposits in vivo. Using a mouse model ...

as organs other than the heart can also be affected by pathogenic amyloid deposition. [Benson 2020;1a] Furthermore, amyloid deposition can occur in any heart tissue, including the endocardium ...

"When it comes to animal models, mice and rats are most commonly used to test experimental amyloid inhibitors. They both have ...

A Potential Solution for Neurodegenerative Diseases. Open Access Library Journal, 12, 1-16. doi: 10.4236/oalib.1112714 . Alzheimer’s Disease (AD), a complex neurodegenerative condition, significantly ...

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and researchers now attribute its symptoms to the deposition of tau amyloid fibrils. Although scientists developed ... Of the tau ...

However, only two related conditions are associated with the simultaneous presence of Bence Jones proteinuria and heavy albuminuria: renal AL amyloidosis and LCDD. [20] It is not uncommon for ...

Although cholinesterase inhibitors do not slow down the disease process, they can help stabilize symptoms. They are often ...