The assembly of the NM construct produced lamellar cross-β-sheet amyloid fibrils based on transmission electron microscopy (TEM), Congo red binding, X-ray fibril diffraction and atomic force ...

1Missense mutations in the β-amyloid precursor protein (APP ... one wonders whether BSB and other nonspecific binders of β-sheet assemblies would discriminate AD from other dementing diseases ...

These sheets are tightly packed, devoid of water, and exhibit a repetitive, pseudo-symmetric arrangement. Unlike other amyloid fibrils, polyQ structures lack the twisting patterns commonly ...