Amyloid precursor protein (APP) plays a central role in Alzheimer ... Here we describe the 1.8 Å resolution crystal structure of the N-terminal, heparin-binding domain of APP (residues 28 ...

Misfolded proteins not only lose their normal physiological functions, but can also acquire new properties that drive pathological processes leading to disease. Amyloid plaques comprising tangled ...

However, the structure of a crystallized protein ... to determine the structures of other small and unstable proteins-including the amyloid-beta peptide that builds up in the brain in Alzheimer's ...

To determine the three-dimensional structure of the proteins ... the structures of other small and unstable proteins like the amyloid-beta peptide that builds up in the brain in cases of Alzheimer ...

More than 20 unrelated proteins can form amyloid fibrils in vivo. All fibrils share cross-β core structure and pathognomonic red-green birefringence when viewed under cross-polarized light after ...

Amyloid deposition occurs under one of ... when an inherently weakly amyloidogenic protein with normal structure is present at normal concentration over a very prolonged period of time, such ...

Protein accumulations do important work in the human body, but something can go wrong and proliferate in those aggregates, ...

Am I at risk if it is genetic? Amyloidosis is a rare condition defined by the abnormal production of proteins that bind together to form amyloid proteins. These amyloids can gather in different ...