Competitive androgen receptor antagonists are used to treat prostate cancer but, even in the presence of such drugs, overexpression of androgen receptors can drive cellular proliferation ...

Peptides are short chains of amino acids that act as signaling molecules in the body. They regulate various biological ...

The androgen receptor (AR) plays a critical role in prostate cancer (PCa) development and progression. Despite the success of androgen-deprivation therapy, remission occurs in almost all cases.

which are a large superfamily of ligand modulated transcription factors and control almost every physiological process of the human body. Regulation of these transcription factors is highly essential ...

"For decades, the goal of endocrine therapy in prostate cancer has been to achieve absolute inhibition of androgen receptor function, the protein that senses testosterone levels," said lead ...

Researchers from Arvinas Inc. reported the preclinical characterization of bavdegalutamide (ARV-110), an androgen receptor (AR)-directed proteolysis targeting chimera (PROTAC) designed to selectively ...

Researchers from AUTOTAC Bio Inc. and affiliated organizations presented preclinical data for ATC-324, a novel ...