Although the mTOR pathway has been characterized in T cells, it has not been well described in other immune cells. In this study, Weichhart et al. investigated how mTOR activity in phagocytes ...

The study reveals that excessive activation of mTOR contributes to kidney injury by inhibiting autophagy, increasing oxidative stress, and promoting inflammation. It examines the impact of mTOR on ...

Although inhibitors targeting elements of the PI3K/AKT/mTOR pathway are promising approaches for leukemia therapy, there is an increasing consensus that these strategies will also have limited ...

It examines the impact of mTOR on podocytes, glomerular mesangial cells, renal tubular epithelial cells, and glomerular endothelial cells—each playing a crucial role in kidney function.