1942—Antergan becomes the first antihistamine tested in humans and goes on the market. 1972—James Black discovers the H2 receptor and characterizes its antagonist, burimamide. 1999 ...

This fourth known histamine receptor now provides an attractive drug target for seasonal allergies, asthma and possibly even cancer. Erica Westly traces the histamine reaction. You have full ...

Ever set off too many of the bitter taste receptors on your tongue? You probably spat out whatever it was in your mouth, and ...

Did you know that human skin can do more than just sense touch? Surprisingly, it can also taste. This incredible ability of ...

In vitro tests have demonstrated that second-generation antihistamines have improved H 1-receptor specificity and a slower dissociation rate compared with first-generation antihistamines ...

A paper published today (November 24) in Cancer Cell reports that high levels of histamine—best known for being released in response to allergens—and one of its receptors are associated with tumor ...

In the following section, the various methods used to evaluate antihistamines illustrate the developmental process for evaluating the efficacy of the H 1-receptor antagonist desloratadine.

"G-protein-coupled receptors are ubiquitous in the function of cells in the body and help us to sense light, flavour and odour. They are also responsible for the human body's reactions to chemicals in ...

Despite concerns on the major neuropsychiatric side effects for long-term use of H1-receptor antagonist (anti-histamine, AH), one of the major therapeutic tools for allergic diseases, their ...