在一项新的研究中，来自利物浦大学的研究人员在了解阿尔茨海默病方面迈出了重要一步。他们揭示了大脑中的机械信号如何受到破坏并可能导致这种疾病。相关研究结果于2024年11月27日发表在 Open Biology 期刊上，论文标题为 “The ...

It is caused by the buildup of harmful proteins like beta-amyloid, which damages brain cells over time. In this study, ...

Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants ...

Amyloid beta (Aβ) peptide, a 40-42 amino acid protein cleaved from the amyloid precursor protein (APP), is a main constituent of the amyloid plaques found in the brains of Alzheimer Disease (AD ...

Amyloid plaques are manufactured by Aβ peptide ... soluble species of Aβ actually represent the key neurotoxins in the APP pathway. 5 Figure 1: In vivo imaging promises to clarify the onset ...

The team of investigators, led by Professor Ben Goult at the University of Liverpool, have examined the role of two proteins ...

A new study from the University of Liverpool represents a significant step forward in scientists' understanding of ...

Amyloid-β (Aβ) precursor protein (APP) is highly sensitive to copper an iron levels. APP may regulate metal ion homeostasis. Metal Binding to APP APP and Aβ have metal-binding sites for copper ...

A new study from the University of Liverpool represents a significant step forward in scientists’ understanding of ...

Study Shares New Insights into Alzheimer’s DiseaseThe team of investigators, led by Professor Ben Goult at the University of ...

It is produced from amyloid precursor protein (APP) by proteolytic processing that depends on the β-site APP-cleaving enzyme 1 and the γ-secretase complex, and is degraded by a broad range of ...