Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants ...
It is caused by the buildup of harmful proteins like beta-amyloid, which damages brain cells over time. In this study, ...
A new study from the University of Liverpool represents a significant step forward in scientists' understanding of ...
The team of investigators, led by Professor Ben Goult at the University of Liverpool, have examined the role of two proteins ...
Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide. Familial Alzheimer's disease (FAD), a rare ...
Amyloid-β (Aβ) precursor protein (APP) is highly sensitive to copper an iron levels. APP may regulate metal ion homeostasis. Metal Binding to APP APP and Aβ have metal-binding sites for copper ...
It is produced from amyloid precursor protein (APP) by proteolytic processing that depends on the β-site APP-cleaving enzyme 1 and the γ-secretase complex, and is degraded by a broad range of ...
Study Shares New Insights into Alzheimer’s DiseaseThe team of investigators, led by Professor Ben Goult at the University of ...
With the first amyloid-targeting drug now approved for Alzheimer’s disease, Alnylam has presented preliminary clinical results with a new candidate that could potentially be dosed as ...
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