You have full access to this article via your institution. Figure 1: Upregulated cellular responses to human IL4 after transfection with the Ile50 variant of IL4Rα compared with the Val50 variant ...

Indiana University School of Medicine researchers have uncovered compelling evidence that children with primary ciliary ...

Asthma tends to run in families, says Dr. Manav Singla, MD, an allergist and immunologist at MedStar Health in Baltimore: ...

The growing body of genetic and clinical data highlight the need to consider the role of structural components of the airway in the onset and propagation of asthma. In particular, the epithelium ...

Asthma is a complex and heterogenous chronic ... T-cells and weaker T2 mediated response from several downstream genes. It therefore, reduces the capability of cells to respond to and further ...

Asthma is generally believed to result from gene-environment interactions. There is consensus that a 'window of opportunity' exists during pregnancy and early in life when environmental factors ...

To date, pharmacogenetic effects identified account for only a small proportion of the genetic variability in response to asthma medication (e.g., CRHR1<3% of corticosteroid response), suggesting ...

Discover how asthma contributes to bronchiectasis development through sinusitis and inflammation. Learn about new findings ...

Researchers have uncovered compelling evidence that children with primary ciliary dyskinesia (PCD), a rare genetic disorder ...

accounting for about 80% of childhood asthma and 50% of adult asthma cases. It's caused by a combination of genetic and ...