The discovery is published in Nature Metabolism under the title "Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity." The study, which was conducted ...
More information: Janine Tutas et al, Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity, Nature Metabolism (2025). DOI: 10.1038/s42255-024-01196-4 ...
but also provides new insights and breakthroughs for potential therapeutic directions in autophagy regulation and diseases such as neurodevelopmental disorders," said Prof. Zhang.
This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...