其中，紧密连接蛋白中的闭合蛋白（occludin）对维持 BBB 的完整性至关重要。然而，在脓毒症发生时，革兰氏阴性菌细胞壁成分脂多糖（LPS）会引发一系列 “破坏行动”，导致细胞间紧密连接被破坏，occludin 等蛋白表达下调，BBB 通透性增加，有害物质趁机进入 ...

Virol. 82, 7591–7600; 2008). When wild-type mice were also injected with LPS, HIV-infected monocytes were able to cross the BBB and enter the brain. In transgenic mice with systemic HIV and ...