It might therefore be speculated that the induction of IgL gene rearrangement and B-cell differentiation is induced solely by the termination of pre-BCR signalling and that no additional pre-BCR ...

In chronic myelogenous leukaemia (CML), a reciprocal translocation between chromosomes 9 and 22 results in a gene encoding BCR–ABL, a fused deregulated kinase that stimulates cellular ...

The addiction of cancer cells to causal gene fusions often results in amplification, in vivo, which can be exploited to reveal unidentified recurrent gene rearrangements. Based on this observation ...

However, neither the Philadelphia chromosome nor BCR-ABL is pathognomonic of CML, as they are present in other human hematologic malignancies. p210 BCR-ABL is found in 95% of patients with CML ...