We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

In addition, Notch is known to participate in cross-talk with other signalling pathways that are essential for cardiac development, including the transforming growth factor-β (TGFΒ)–BMP ...