Xu and colleagues, therefore, conducted a randomized, double-blind, placebo-controlled crossover study to evaluate the efficacy of baclofen, a potent γ-aminobutyric acid receptor agonist ...

Baclofen is rapidly and completely absorbed following enteral administration. It has a mean half-life of 3.5 hours. Baclofen is metabolized by the liver and eliminated by renal excretion.