Choosing any of these characters will ensure they have the best shot at succeeding during their run. The Binding Of Isaac has withstood the test of time, but even big fans might find it growing stale.

These are some of the most effective unlocks players won't want to miss. The Binding Of Isaac offers lots of characters for players to use in their runs, and these are the best of them.

Reviewed on November 25 The time I’ve spent with Binding of Isaac: Rebirth has been non-stop fun and surprises, with just a tad too much frustration when I lose a rare item. But even when it ...