Although it is clear that beta cell dysfunction is the main factor responsible for the progression to hyperglycemia, insulin resistance predates beta cell dysfunction, and reversibility of insulin ...
Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible ... toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in ...
Women who have gestational diabetes have increased risk of type 2 diabetes in the years after delivery. Those who go on to develop the chronic disease fall into three “clusters,” each with a distinct ...
About Menin’s Role in Diabetes Loss of functional beta cell mass is a core component of the natural history in both types of diabetes — type 1 diabetes (mediated by autoimmune dysfunction ...