Under conditions of low unfolded protein stress, the lumenal domains of PERK and IRE1 are in complex with the endoplasmic reticulum chaperone BiP, whose binding correlates with the inactive state ...

Interaction of nascent secretory proteins in the ER with molecular chaperones, such as BiP or the lectin chaperones calnexin and calreticulin, is likely to play a central role in the decision ...

Additionally, recombinant BiP, an ER-resident chaperone, has demonstrated promise in enhancing gut barrier integrity and reducing immune cell infiltration in the intestine. The study also ...