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探秘 ALS-FTLD:C9ORF72 突变下线粒体 DNA 突变的 “神秘旅程”
为探究 mtDNA 突变在 ALS - FTLD 发病机制中的作用,研究人员用 hiPSCs - 衍生脑类器官研究,发现 C9ORF72 突变星形胶质细胞 mtSNV 负担高,或助力靶向治疗。
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