The mutant proteins that cause polyglutamine disease bind CREB-binding protein (CBP), a key transcriptional co-activator for neuronal survival factors. This results in a loss of CBP-dependent ...

This closed configuration leads to repression of viral gene transcription, resulting in a low level of viral replication. PRMT1, arginine methyltransferase 1; CBP, CREB binding protein; HDAC1, histone ...