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ZEB1 通过 MCSF-CCL18 轴促进卵巢癌免疫逃逸:机制新解与治疗曙光
ZEB1 信号通路在卵巢癌样本中的表达 :通过 Western blot 和免疫组化分析发现,与健康卵巢细胞相比,卵巢癌细胞中 ZEB1、MCSF 和 CCL18 的表达水平显著升高;且在高级别卵巢癌样本中,这些蛋白的表达水平也明显高于低级别样本。这表明 ZEB1 相关信号通路(MCSF - CCL18)可能在卵巢癌细胞的恶性表型中发挥重要作用 12 。
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