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抗 CD19 外泌体递送系统:突破血脑屏障治疗中枢神经系统淋巴瘤的新 ...
体内实验中,颅内原位 CNSL 小鼠模型经治疗后,anti - CD19 - Exo - MTX 组疾病负担减轻,生存期延长,且在脑脊液和脑组织中药物浓度更高、更稳定,Ki - 67 增殖指数也表明其能更有效地抑制 CNSL。同时,该组小鼠恶病质症状较轻,体重下降较少。此外,anti - CD19 - Exo ...
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