生物通18 天
CD28 共刺激在制备肿瘤免疫治疗 CAR-NK 细胞中更具优势
为探究 CAR 设计对 NK 细胞的适用性，研究人员对比 CD28 和 4-1BB 共刺激，发现 CD28 更优，为 CAR-NK 疗法提供新思路。 在肿瘤治疗的战场上，免疫疗法近年来可谓大放异彩，其中嵌合抗原受体 NK 细胞（CAR-NK）疗法更是潜力无限。它就像给 NK 细胞（自然杀伤细胞 ...
Nature1 年
Transforming the CAR-T landscape: platforms pioneer state-of-the-art immunotherapeutics
When expressed in CAR-Ts, this chimeric receptor competes with inhibitory endogenous CTLA4, while simultaneously delivering a stimulatory CD28 signal to the CAR-Ts (converting a negative signal to ...
来自MSN2 个月
A battle of rafts: How molecular dynamics in CAR T cells explain their cancer-killing behavior
"We looked at two different types of CAR T cells. The first, CD28.ζ-CART cells, are like sprinters. They kill cancer cells quickly and efficiently, but their activity is short-lived. The second ...
来自MSN2 个月
Research explores molecular dynamics of CAR T cells in cancer treatment
We looked at two different types of CAR T cells. The first, CD28.ζ-CART cells, are like sprinters. They kill cancer cells quickly and efficiently, but their activity is short-lived. The second ...