具体来说，CD8 + T细胞通过其T细胞受体（TCR）识别肿瘤细胞表面特有的抗原，启动细胞毒性反应，释放细胞毒性分子如穿孔素和格朗津B（GZMB），这些 ...

T 细胞功能：研究人员检测肝癌患者组织发现，肿瘤相关 ATF4 水平与 CD8? T 细胞毒性所需的颗粒酶 B（Granzyme B，GZMB）表达呈负相关。体外将 CD8? T 细胞与肝癌细胞直接共培养，发现肝癌细胞中 ATF4 过表达会降低 CD8? T 细胞中 GZMB 和干扰素 γ（Interferon gamma，IFNG ...

(b) A closer look reveals eTregs control CD8-EM cells by stopping their division and reducing GzmB while maintaining CD27. (c) Dividing eTregs increase CD98, GLUT1, and CTLA4 proteins, and shows ...

reduced their terminal exhaustion differentiation and enhanced the ability of terminally exhausted CD8(+) T cells to produce and secrete IFN-γ and GZMB. In addition, FP008 showed encouraging ...