结论 肿瘤浸润的 CD8 + T 细胞在多种癌症中发挥肿瘤抑制作用，高 CD8 + TIL 水平与大多数肿瘤的良好预后相关。然而，TIME 的免疫抑制环境抑制了 CD8 + TILs 的抗肿瘤活性，促进肿瘤进展。虽然多种癌症免疫疗法可恢复和增强 CD8 + T 细胞的抗肿瘤免疫，但由于 TIME 的 ...

沉默KLF2促使CD8 T细胞沿着不同的分化路径发展，引导它们远离杀伤性T细胞，进入一种称为衰竭的功能失调状态，这种状态会降低这些细胞对抗感染和 ...

The cells were counterstained with monoclonal antibody against CD8-FITC and analyzed by flow cytometry. Isolation of TIL from RCC patients and detection of RCC-26-specific T cells. Riddell ...

To examine underlying mechanisms of activity for the doublet regimens, investigators studied transcriptional and proteomic ...