Effects of CENP-E functioning on fibrous corona. Top: functionally normal CENP-E (farnesylated) promotes the formation of the fibrous corona and facilitates chromosome alignment. Bottom ...

Centromeric chromatin is specified by the histone H3 variant CENP-A (centromere protein A). But how CENP-A is specifically targeted to and assembled at centromeres — and how centromeres are ...