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Nature
1 年
A trinucleotide repeat biosensor
A small-molecule ligand that binds to a (CAG) n hairpin repeat is the basis of a biosensor to detect repeat length, which may help diagnose trinucleotide repeat disease severity. DNA trinucleotide ...
technologynetworks
8 天
DNA Destabilizing Proteins Implicated in Huntington’s Disease Progression
APOBEC enzymes, which normally help fight viral infections by mutating viral DNA, cause repeat expansions and are unusually ...
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