长期以来，科学家们对塔里木兔如何适应干旱环境充满好奇。细胞色素 P450（Cytochrome P450，CYP450）作为一类在生物体内发挥重要作用的代谢酶，其代谢产物如 19 - 羟基二十碳四烯酸（19-hydroxyeicosatetraenoic acid，19-HETE）、20 - 羟基二十碳四烯酸（20-HETE）和环氧二十碳 ...

450_{\\text{SU}1}$ (CYP105A1) was expressed in transgenic tobacco (Nicotiana tabacum). Because this P450 can be reduced by plant chloroplast ferredoxin in vitro, chloroplast-targeted and nontargeted ...

For decades, people on certain medications have had to avoid grapefruit due to its interference with drug metabolism. Now, ...

St. Patrick’s Day has passed. If your liver is still functional (meaning you didn’t down too many Salty Dogs) and you're ...

CONCLUSIONS: Cytochrome P450 3A4 is a primary enzyme responsible for the metabolic clearance of quetiapine. Quetiapine pharmacokinetics were affected by concomitant administration of ketoconazole ...

The research of D. Fernando Estrada, PhD, associate professor of biochemistry, has been recognized by the American Society for Pharmacology and Experimental Therapeutics (ASPET).

Cytokinetics (CYTK) announced five presentations related to aficamten, an investigational cardiac myosin inhibitor, and hypertrophic ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...