Aeglea BioTherapeutics is a leader in the creation and development of novel human enzymes ... with a direct cell-killing effect—and will help guide the selection of future cancer indications ...

However, when the researchers blocked an earlier step in glycolysis, the enzyme glucose-6-phosphate isomerase, this had no effect on the growth of the cancer cells. "The glycolytic enzyme aldolase ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme—P4HA1 prolyl hydroxylase, is strongly induced in CD8 + T cells in solid cancer, the primary ...