2025年2月28日，哈佛大学医学院Dana-Farber癌症研究所的诺奖得主William Kaelin、免疫疗法和癌症疫苗先驱Catherine Wu以及Broad研究所蛋白质组学专家Steven Carr的研究团队（共同一作为蒋沁沁、David A. Braun和Karl R. Clauser）在Cell杂志上发表了文章HIF regulates multiple translated ...

编者按：透明细胞肾细胞癌（ccRCC）普遍与VHL通路失调相关，这会导致HIF-2α过度表达并上调多种致癌通路。而针对HIF-2α的治疗策略，如贝组替凡等 ...

下面来看具体的研究结果： VHL 调节的 miRNA 谱分析：研究人员对 VHL 缺陷的 ccRCC 细胞系 RCC4 及其表达功能性 VHL 蛋白的同基因细胞系 RCC4 VHL 进行小 RNA 测序，发现 352 个 miRNA 中有 75 个差异表达。通过对 ccRCC 患者（TCGA-KIRC 和 CPTAC3 队列）的 miRNA 测序数据进行分析 ...

ccRCC 亚型的鉴定：对 RASSF3、RASSF6、RASSF8 和 RASSF9 进行多因素回归 ... 高评分组患者在 TTN、MTOR 和 SETD2 等基因的体细胞突变率更高，而 VHL 和 PBRM1 突变率较低。此外，高评分组患者的趋化因子表达较低，免疫细胞浸润减少，糖酵解、脂肪酸代谢等代谢通路更活跃。

RCC is associated with von Hippel-Lindau (VHL) disease, a hereditary condition ... The trial is seeking to enroll patients with ccRCC whose cancer is not suitable for surgery or has spread ...

as a single agent for the treatment of adults with von Hippel-Lindau (VHL) disease and advanced clear cell renal cell carcinoma (RCC). Welireg is intended for adults with VHL disease who need ...

The trial marks a significant milestone for Inceptor Bio's efforts to address the unmet medical needs of patients with clear cell Renal Cell Carcinoma (ccRCC) IB-T101 is an autologous CD70 CAR-T ...

The cohort had a median age of 65 years (IQR 53–68), with 74% male and 82% Caucasian. Of the total 808 gene panel, 15 genes were mutated by >5% in the entire cohort, with PBRM1, SETD2, KDM5C, TP53, ...