通过蛋白质免疫印迹、免疫金透射电子显微镜（Immunogold transmission electron microscopy，IG - TEM）和酶联免疫吸附测定（Enzyme - linked immunosorbent assay，ELISA）等技术证实了 Exo CD47 的外泌体特征，且其 CD47 蛋白表达水平显著高于对照 Exo。 体外实验中，将 Exo 和 Exo CD47 与 ...

在前几年，“别吃我”信号通路CD47-SIRPα，可谓是最热门的开发领域之一。 随着诸多管线的临床推进安全性问题频发，吉利德、天境医药等先锋企业 ...

Sino Biological has used the Beacon ® single B cell platform to screen various CD47 antibodies that bind to protein and tumor cells. In the blocking assay, CD47 antibodies successfully blocked ...

Other studies of the CD47-directed antibody in large B cell lymphoma, multiple myeloma and solid tumours are not affected as they don't include azacitidine as a study drug. "While no clear trend ...

No. EP-101) and CD47: SIRP alpha (Cat. No. EP-102) inhibitor screening assay kits that can perform high-throughput screening of neutralizing antibodies or small molecules. Anti-LAG-3 MAb (Human ...

The researchers looked at stem cells from AML patients at the Stanford Medical Center to see if they also expressed CD47. “They all did,” says Weissman. After demonstrating in cell culture experiments ...

Gilead is dealing with more turbulence in its development of CD47-targeting antibody magrolimab, with a partial clinical hold placed on the drug by the FDA in acute myeloid leukaemia (AML).

Also, Nest1 outcompeted CD47’s ligand, showing a particularly strong interaction that could be regulating ... To find out, they incubated macrophages with and without Nest1 and tagged red blood cells ...