Our News & Views discussed a recent paper 6 that clearly stated that the existence of a putative membrane ... receptor couples to a common intracellular signaling pathway in four different cells ...

Membrane-anchored LT-scFv retain their binding specificity and mediate functional interactions between the modified cell with the artificial ‘receptor’ and the cells bearing the corresponding ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with ...

Alterations in thyroid gland function result from the action of stimulating or blocking autoantibodies on cell membrane receptors. Three principal thyroid autoantigens are involved in AITD.

Research in our laboratory aims to characterize the molecular mechanisms underlying cell-to-cell interactions and signal transduction across the cell membrane. We are particularly interested in ...

Glycoproteins typically bind to receptors on the membrane of a host cell. Viruses that do not bud from the host cell membrane do not have an envelope, so they are called “naked” or ...

It shakes and wiggles from within its straitjacket, extending a few fingers to activate a neighboring receptor despite being ...

When bound to the receptor, toxins can act at the cell membrane by interfering with signal transduction pathways, pore formation or enzymatic activities on membrane compounds. Various enterotoxins ...

Researchers have developed a new microscopic method to observe the interactions of therapeutic antibodies with target molecules on tumor cells.

Other than priming certain viral surface proteins for fusion, cleavage generates a carboxy-terminal RXXR sequence. This C-end Rule (CendR) motif is known to bind to neuropilin (NRP) receptors on the ...

Membrane proteins are key targets for therapeutic intervention using antibody biologics. Over 60% of FDA-approved drugs act ...