Our research focusses on mitochondria, cellular energetics, reactive oxygen species and their roles in physiology, disease, and aging. We have approached each by using the tools of biochemistry, ...

A multiprotein complex is essential for regulating cellular responses to oxygen deprivation ... of the National Academy of Sciences. Hypoxia, when cells are deprived of oxygen, is a key feature ...

Increased dietary folic acid intake may lead to adverse health effects, including inflammation and neurotoxicity, ...

HIF1α is a subunit of HIF, or hypoxia-inducible factor, that is known to play a crucial role in orchestrating cellular responses to hypoxia. Shi and colleagues showed this key role for HIF1α in ...

Effect of Hypoxia on HIV-1 Hypoxia inhibits HIV-1 by decreasing CDK9/cyclin T1 activity. The effect of hypoxia could be due to deregulation of protein phosphatase-1 and/or increased expression of p27.