"Although MFN2 is a leading causative gene in Charcot-Marie-Tooth, most other genes linked to the disease do not encode mitochondrial proteins. This makes it less surprising that MFN2's connection ...

Charcot-Marie-Tooth (CMT) disease, a group of heritable disorders ... novel therapeutic strategies could be developed to alleviate the symptoms of CMT1A and to improve the quality of life for ...

Dysfunction of these nerves can cause spontaneous, inappropriate signals or loss of signals, leading to symptoms such ... nerve condition called Charcot–Marie–Tooth disease type 2 (CMT2).

Charcot-Marie-Tooth disease is a genetic neurological condition ... so people are born with one or more genetic mutations that cause CMT. But symptoms may not appear until someone is in their ...