Thus, the 30-nanometer fiber may be highly irregular and not quite the uniform structure depicted ... is therefore important for cells to have means of opening up chromatin fibers and/or removing ...

Orthogonal acute inducible degradation cell lines are used to delineate ... formation was revealed and gradual emergence of chromatin structure recapitulated by polymer simulations.

From sequence to structure Inside the cell nucleus, DNA and proteins form a complex called chromatin, which has several levels of organization, allowing cells to cram 2 meters of DNA into a nucleus ...

Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...

Each cell of the human body contains two meters of DNA. The whole secret lies in the intricate three-dimensional arrangement that allows DNA strands to be efficiently organized and compacted within ...

The chromatin-bound proteome of embryonic stem cells transitioning to 2C-like cells uncovers chromatin regulators involved in heterochromatin formation.

The scientists observed that chromatin ... of each cell, the genome is folded in such a way as to form thousands of tiny nanoscale 'packing domains,' the three-dimensional structure of which ...

Varshavsky studied chromatin structure and wanted to develop new methods to detect the DNA-protein interplay in intact cells. Motivated to better understand chromatin structural organization, ...

These discoveries could have important medical implications, including diagnostic tests for causes of infertility linked to genome folding.

Despite extreme local changes to the protein brought by aging-related PTMs, the overall structure and integrity of chromatin seemed unaffected. However, enzymes that typically interact with it ...