For instance, deletions that span a centromere result in an acentric chromosome that will most likely be lost during cell division. As with duplications, deletions can affect gene dosage and thus ...

We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated ...

DSBs and DNA Rearrangements in Cancer Cells Together with a variety of other molecules, ATR and ATM kinases are key factors for the surveillance of DNA replication, and prevent chromosome breakage ...