研究结果表明，胆固醇24-羟化酶CYP46A1在帕金森病中的α-突触核蛋白病理进展中起着关键作用，突显了其作为帕金森病治疗靶点的潜力。 在一项新的 ...

24-OHC is produced from cholesterol by the actions of an enzyme, cholesterol 24-hydroxylase (CYP46A1), and the researchers suggest that blocking the activity of 24-OHC or preventing the metabolite ...

Scientists identified that elevated levels of the enzyme CYP46A1 and its associated compound 24-OHC worsen the condition. Additionally, they observed that these levels increase with age in mouse ...