or an alkylating agent, that causes mutations in DNA. Those mutant cells were then screened for sensitivity to DNA damaging agents. Many mutant cells were identified, and careful genetic studies ...

Therapeutics announced plans for a Phase 2 trial evaluating the combination of stenoparib with temozolomide, a DNA-alkylating ...

Melphalan, chlorambucil and busulphan form a class of compounds known as alkylating agents. Later, in the 1960s, Professors Philip Lawley and Peter Brookes would demonstrate that these drugs worked by ...

Melphalan is an alkylating agent with cytotoxic action that appears to be related to the extent of its interstrand cross-linking with DNA, probably by binding at the N7 position of guanine.