本文聚焦核结构、基因组组织与 DNA 双链断裂（DSB）修复，揭示相关动态调控机制及潜在治疗意义。 # 核结构、基因组组织与 DNA 双链断裂修复的动态机制关联 在癌症、衰老以及其他伴有 DNA 损伤增多的临床情形中，细胞核形状以及染色体在核内的空间组织变化 ...

该成果对理解减数分裂重组机制意义重大，值得科研读者一读。 在生物的繁衍过程中，减数分裂（Meiosis）起着至关重要的作用，而 DNA 双链断裂（DSB）的形成则是减数分裂重组的起始关键步骤。SPO11 作为引发减数分裂重组的 DNA 切割亚基，自发现以来已有 25 年之 ...

Of the many types of DNA damage that exist within the cell, probably the most dangerous is the DSB. These result from exogenous agents such as ionizing radiation (IR) and certain chemotherapeutic ...

同源重组起始于程序性DNA双链断裂（Double-Strand Break，DSB）的形成。早在1997年，就有研究发现Spo11为催化酵母减数分裂DSB形成的关键蛋白；并揭示其在 ...

To study DSB repair using this system, researchers treat cells with a dose of IR high enough so that the genomic DNA is shattered, leaving no intact chromosomal bands. Cells are then allowed time ...

在减数分裂过程中，Spo11诱导的程序性DNA双链断裂（DSB），进而启动减数分裂重组使得同源染色体之间的遗传物质交换，极大地促进了遗传多样性。

该研究首次在实验室环境中成功模拟并解析了减数分裂过程中DNA双链断裂（DSB）形成的分子机制，攻克了生殖生物学领域长达数十年的科学难题 ...

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

But Storici's team found that RNA can also help cells repair a severe form of DNA damage called a double-strand break, or DSB. A DSB means both strands of the DNA helix have been severed.

The dimeric MR complex composed of Mre11 nuclease and Rad50 ATPase detects and processes diverse and obstructed DNA ends by initiating DSB repair by either end joining or homologous recombination. To ...

We examined DSB repair in a Brca1-deficient mouse embryonic stem (ES) cell line (Moynahan et al. Molecular Cell. 1999). Whereas nonhomologous repair of DSBs is intact in these cells, homology-directed ...